Direct Evidence for Intra- and Intermolecular Disulfide Bond Formation in the Human Glucocorticoid Receptor

Intermolecular disulfide-bond formation in human FICD modulates the activity of the hyperactive E234G mutant

Protein cross-linking by self-assisted intermolecular disulfide bond formation.

Storage of proteins is a physiological means to provide a reservoir for regulated utilization by the organism. Examples are the intracellular storage of exportable proteins in secretion granules, e.g., in exocrine glands, and the extracellular deposition of secretory proteins, e.g., of thyroglobulin (TG) in the lumina of thyroid follicles. In all cases, tight packaging of protein molecules is o...

The thioredoxin boxes of thyroglobulin: possible implications for intermolecular disulfide bond formation in the follicle lumen.

Multimerization of thyroglobulin (TG) takes place extracellularly in the thyroid follicle lumen and is regarded as a mechanism to store TG at high concentrations. Human thyroglobulin (hTG) has been shown to multimerize mainly by intermolecular disulfide cross-links. We recently noted that TG of various mammalian species contains three highly conserved thioredoxin boxes (CXXC). This sequence is ...

Disulfide bond formation in the eye lens.

The disposition and disposal of the -SH groups of the lens during aging and cataractogenesis have been investigated by laser Raman spectroscopy as a noninvasive microprobe in the intact living lens. In this procedure -SH and -S-S- give unique discrete Raman signals (at 2580 and 508 cm-1) that may be used to calculate relative concentrations in a very small volume of the lens. We present evidenc...

simulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water

abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...